Research in humans suggests that chronic ecstasy use can lead to changes in brain function, affecting cognitive tasks and memory. Ecstasy can also lead to symptoms of depression several days after its use.
Since about 1990, GHB (gamma hydroxybutyrate) has been abused in the U.S. for its euphoric, sedative, and anabolic (body building) effects. It is a central nervous system depressant that was widely available over-the-counter in health food stores during the 1980s and until 1992.
Methadone mimics many of the effects of opiates such as heroin.
The short-term physiological effects of cocaine include constricted blood vessels; dilated pupils; and increased temperature, heart rate, and blood pressure.
The effects of alcohol are experienced differently for each individual depending on their size, sex, body build, and metabolism.